Tips on choosing the right fertility clinic for you

When the time comes to choose a clinic, there are a number of factors to consider, with one of the most important being success rates.

Pregnancy rates will often be quoted on a website, but you also need to look at the live birth rate – the number of babies born per completed cycle of treatment. Pregnancy rates are usually higher than live birth rates, but it’s the chance of having a baby from treatment that you are actually interested in. A call to the clinic should give you an indication, for your age of how likely it is that you would have a baby from one treatment cycle.

It is really important that you trust the clinic and get a good feel for the team. If you have an opportunity to visit a clinic or attend an information evening, you should get a good sense of the clinic and its ethos.

Consider the opening times and the location of the clinic. It is important that the clinic is within reasonable distance of your home or work. It’s best to avoid long journeys as they will result in added stress, time off work, expense etc.

The cost of treatment is a very important factor to consider. Enquire if there will be additional costs involved or added extras, as you do not want to be faced with an unexpected bill at the end of your treatment.

You also need to be sure that the clinic offers the full range of treatment options. In addition to offering IVF, the clinic should also provide the less invasive treatments. If you are aware of a specific problem that is causing your fertility issues or contributing to it, it is always best to make a phone-call and ensure they are the best clinic to treat your concern.

http://www.her.ie/health/start-seeking-fertility-help/309081

15 things to know about periods

Getting to know your menstrual cycle can provide a wealth of information on your reproductive and fertility health, according to fertility nurse specialist Mary McAuliffe. For couples who are trying for a baby, she says that keeping a diary of your monthly cycle can be a valuable method of boosting your chances of conception. Here are 15 things to note about your menstrual cycle.

1 Get to grips with your cycle

Every woman should get to know their menstrual cycle and become familiar with the subtle changes their body goes through on a monthly basis. A regular cycle is usually 28-30 days long with ovulation occurring on day 14-16. I encourage all the women I see to keep a menstrual diary. Take note of the length of your cycle, taking ‘day one’ as the first day of your period. Keep track of how many days your period lasts for, and how many days from day one of a cycle to day one of the next cycle.

Any pain, vaginal discharges, or other symptoms should also be noted. This information can be helpful if you need to seek assistance when pin-pointing fertile days of your cycle, or if you are attending the GP for health concerns or pregnancy delay.

2 The biology

At the beginning of your cycle, your body starts producing oestrogen, which is necessary for the lining of the uterus to thicken in preparation for pregnancy. Once the oestrogen reaches a certain level, your body triggers an ‘LH surge’ – the release of the Luteinising Hormone. Within 48 hours of the LH surge, your ovary releases an egg (ovulation) which travels into one of your fallopian tubes. If fertilised by sperm, the fertilised egg may implant and hopefully a healthy pregnancy will follow. If there is no fertilisation, the womb lining is shed and the cycle, day one, begins.

3 PMS

Premenstrual syndrome affects the majority of women. It is caused by the changes in hormone levels that occur during the menstrual cycle. Common symptoms include bloating, cramps, headache, irritability, food cravings and fatigue.

Using a menstrual diary to record PMS symptoms will get you in tune with how your body normally reacts during your cycle, and will alert you to any new symptoms, as well as methods that help you cope.

For some, exercise and dietary changes along with supplements can make a big difference to negative hormonal symptoms.

4 Ovulation

If you have a regular 28-day cycle, ovulation will occur on day 14. If your cycle is longer or shorter, count back 14 days from day one to find the day on which you ovulate. Your ‘fertile window’, or the time frame in which you have the best chance of conceiving, is two days before the day you ovulate through to two days after, so days 12 to 16 in a regular cycle. Remember that sperm lives for much longer than the egg.

5 Irregular periods

With the exception of women who are pregnant, going through menopause, on the contraceptive pill, or women who are known to have polycystic ovaries, every woman should have a period once a month. If you find you are skipping months and your periods are very erratic, you should see your GP or a fertility specialist. Very irregular periods can be an indication of an underlying health problem that your GP can investigate. Often a simple blood test can help shed light on the cause for irregularities. If you are concerned about your fertility, consider a fertility check which can give you reassurance or arm you with more knowledge for the future.

6 Amenorrhea

A diagnosis of secondary amenorrhea will be made after missing at least three periods when a woman was previously menstruating. This can either be caused by an issue with reproductive organs, or problems with glands that regulate hormones. Over-exercising, extreme weight loss, excessive stress or illness are also triggers.

Normally, treating the underlying issue will resolve secondary amenorrhea. Primary amenorrhea is when menstruation has not occurred by age 16 and should be investigated. Anyone who experiences either primary or secondary amenorrhea should seek medical advice.

7 Family history

Ask your mother or any older sisters about their menstrual history. For example, if your mum went through an early menopause, then there is a risk that this may happen for you too.

8 Your period after the pill

Seek medical advice if you have not started menstruating again within four to six months of stopping the contraceptive pill. Also pay attention to the length of your cycle. Has it changed? This can be especially important if you are trying for a baby, as your ‘fertile window’ might be different to what it was before you were on the pill. Keeping a menstrual diary will help with this.

9 Foods that can help regulate your period

Ensure your diet includes plenty of omega-3 essential fatty acids, found in oily fish such as salmon, flaxseed, walnuts and avocados. This helps with blood flow which will assist in the movement of the egg from the ovary. Eat plenty of plant protein, found in legumes and nuts, which will help with regulating your hormones.

Try to increase your vitamin D intake by getting out in the sunshine or taking a supplement – this can help with healthy egg development. Eating a little 70pc dark chocolate, which contains flavonoids, can help with increasing microcirculation in the ovaries. A healthy diet and plenty of water will also help with relieving PMS symptoms.

10 Lifestyle tips that can help regulate your period

There are a number of simple lifestyle tips which can help to regulate your period, and will also improve your reproductive and general health. First of all, quit smoking. The blood vessels in your ovaries are tiny and can be damaged easily by smoking, which can affect your blood flow. Also maintain a healthy weight; obesity can negatively affect ovulation, while being underweight can be just as bad.

Engage in a healthy rate of exercise that you enjoy and avoid vigorous exercise. Keeping active will also reduce stress levels, which can adversely affect your cycle.

11 Teenage girls and periods

Between the ages of eight and 13, a girl will normally go through puberty. Generally speaking, about two years after a girl’s breasts develop, she should experience her first period. The medical term for this is menarche; when all parts of the girl’s reproductive system have matured and are working together.

Around six months before a girl gets her first period, she may notice a clear vaginal discharge. This is normal and should not cause worry, unless it is causing itchiness or has a strong odour. Normally, a first period should not last longer than seven days. If it does, or if dizziness or a racing pulse is experienced, medical advice should be sought.

12 Menopause

This is a normal condition that all women experience over the age of 40 and usually at around age 51. As every woman is born with a finite number of eggs, a woman eventually stops ovulating and, therefore, menstruating.

Perimenopause begins a number of years before menopause, and in the final one to two years, women will experience menopausal symptoms such as hot flushes, mood swings, insomnia and fatigue. Once the period stops for 12 months, the woman enters the postmenopausal stage and the symptoms should cease.

13 Early menopause

Around one-in-100 women will experience early menopause – before the age of 40. The symptoms are very similar to menopausal symptoms: hot flushes, night sweats, mood swings and low libido. Early menopause can be genetic, so it’s a good idea to chat to your mum about her history. There are also lifestyle factors such as smoking or being very underweight, and other factors including chromosome defects or autoimmune diseases.

14 Clues to cervical cancer symptoms

There are a number of symptoms of cervical cancer that can become apparent if you are tuned in to your menstrual cycle. For example, irregular bleeding in between your periods or a discharge that is streaked with blood. If a woman who has gone through menopause notices this type of bleeding, it is never normal and they should consult a GP. Any unusual vaginal discharge should also be taken note of, especially discharge that is white, watery, brown, or smells. If this persists, medical advice should be sought.

15 When to expect a period after having a baby

A woman’s period will typically return about six to eight weeks after giving birth, if she is not breastfeeding. If she does breastfeed, the time it takes for a period to return can vary. Some women might not have a period the entire time they breastfeed. But for others, it might return after a couple of months. If you are not breastfeeding and do not get your period after three months, you should speak to your GP.

http://www.independent.ie/life/health-wellbeing/15-things-to-know-about-periods-34960431.html

The ethics of fertility

Dr John Waterstone, Medical Director of the Waterstone Clinic, tells Catherine Reilly about the challenges facing fertility services and the urgent need for regulation

The area of fertility is rapidly changing. Science is delivering new possibilities, but the efficacy and affordability of some treatments have created cause for concern.

Questions marks have recently surrounded pre-implantation genetic screening (PGS) or aneuploidy screening, for example, which is used by some clinics in Ireland and internationally to seek to identify chromosomally normal and abnormal embryos.

In an interview with the Medical Independent (MI), Waterstone Clinic’s Medical Director Dr John Waterstone said routine PGS is “not warranted”. He said PGS is often marketed in the US as a ‘standard’ element of IVF treatment, which he found disquieting.

Dr Waterstone, who is President of the Irish Fertility Society (IFS) but spoke in a personal capacity, said the Waterstone Clinic would only recommend PGS for a small cohort in particular clinical circumstances.

“Personally, I am worried about the role of PGS full-stop,” Dr Waterstone told MI. “I don’t know just how promising it is, I don’t know how beneficial it is.”

Confusion

Mosaicism has recently emerged as a particular uncertainty in respect of PGS. Dr Waterstone noted that cases are being reported internationally of ‘mosaic embryos’ developing into healthy euploid newborns.

“When you do PGS on an embryo, you take out two-three-four-five cells from the embryo, usually from the part of the embryo that is going to form the placenta, and you do that at the blastocyst stage where there are maybe 150 cells present,” outlined Dr Waterstone.

“But some embryos contain a mixture of different cells; some of the cells are genetically normal and then other cells have an extra chromosome, or a chromosome too few.”

The growing evidence around mosaicism has thrown the area of PGS into confusion, he indicated.

“So for me, as Medical Director of Waterstone Clinic, we are proud that this is a technique we can do successfully but I am not at all certain right now, in 2016, about how the whole thing is going to pan-out with regard to PGS.”

PGD

Dr Waterstone said the centre was very happy with its pre-implantation genetic diagnosis (PGD) programme, which he said offers clear benefits.

“The couples are coming to you with a very real risk, usually a 25 per cent risk or a 50 per cent risk, that any baby they have would be affected by a very serious genetic condition. PGD is a good thing in my mind; there is no debate there.”

Dr Waterstone said the centre is doing a small number of PGD procedures. Waterstone Clinic is planning a relocation to a larger site that will facilitate a greater volume of work in this realm, he said.

“We are going to move to a new unit on the outskirts of Cork. We are opening there in January and our laboratory space is going to go from 300 square feet to about 1,400 square feet, so we will have a whole lot more space and a dedicated area for PGD.”

The centre has adopted the list of conditions approved for PGD by the UK fertility services regulator, the Human Fertilisation and Embryology Authority (HFEA). Dr Waterstone said there was a pressing need for long-awaited legislation and regulation around assisted human reproduction (AHR). The emergence of expensive ‘add-ons’ in IVF treatment is a particular concern.

In the UK, he noted, the HFEA has expressed alarm that certain IVF units are recommending extra treatments with the aim of “extracting more money from patients but without measurable benefits”.

Dr Waterstone said examples included intracytoplasmic morphologically-selected sperm injection (IMSI), which is not supported by data. He was also of the view that no additional cost should be associated with time-lapse incubators.

Commercialisation

“What I have been saying to the Department of Health is we certainly need regulation of IVF, but the most pressing concern is the commercialisation of IVF. The regulations that are introduced must address that issue, because that is one of the most pressing concerns — that couples coming through are maybe being exploited commercially by clinics that just want to maximise profit, rather than just maximise the outcomes for their patients.

“That to me is something that urgently needs to be addressed but which hasn’t really been addressed by legislation and regulation in other countries… It is a very practical issue for couples who are cash-strapped and finding it hard to afford IVF anyway and meanwhile they are confused as they go through and are being offered these add-ons.”

Currently, it is unclear when the Department will publish its draft legislation on AHR. MI understands drafting of the bill’s General Scheme is ongoing and there will be consultation after its publication.

“I hope they are making progress but from a pragmatic point of view, I cannot see that the Government are going to be eagerly trying to legislate on a contentious area, seeing as they are not in a strong position anyway,” Dr Waterstone commented.

IVF stakeholders were invited to a meeting in Hawkins House in July 2015. At that point, recalled Dr Waterstone, the Department already had a “framework for legislation”. “We in the IVF community were slightly upset and surprised that the plans had advanced so far without them seeking advice from us,” said Dr Waterstone of this meeting.

Many felt there was also insufficient consultation on legislative AHR provisions in the Children and Family Relationships Act 2015, developed by the Department of Justice. The Act provides for a National Donor-Conceived Person Register and bans use of anonymous donor gametes in Ireland. These parts of the legislation have not yet commenced.

“I personally think it was bad legislation; I think it was a missed opportunity for good legislation. I think it is far too restrictive, it actually infringes people’s constitutional right to privacy and autonomy,” said Dr Waterstone.

Currently, many fertility clinics in Ireland use sperm from Denmark and the majority of donors choose to be anonymous.

“The initiative from the Department of Justice, which is in law but not actually introduced, tries to ban anonymous donation. In other words, every donor in the future has to be someone who could be identified. I personally think it is over-intrusive, it is too dogmatic. I think people should be allowed a choice.”

The majority of heterosexual couples using donor sperm have opted for anonymous donors. This option is also taken by a “significant minority” of single women and same-sex female couples, he outlined.

Dr Waterstone added that around 1,000 couples per year go abroad for egg donation, usually to Spain or the Czech Republic, where it is anonymous by law.  The Department of Health, which will oversee implementation of this part of the legislation, has said the provisions relating to donor-assisted human reproduction, including those pertaining to non-anonymity and the National Donor-Conceived Person Register, will only apply where the donor-assisted human reproduction procedure takes place in Ireland.

The Department contends that the provisions reflect international best practice.

However, Dr Waterstone said the need to go abroad to access anonymous donor sperm or eggs would mitigate against less well-off people.  There is also a possibility that people will not involve clinics in the process at all, he said.

“We are also concerned in the Irish Fertility Society about ‘do-it-yourself’ donor sperm treatment for women. Say, a single woman who wants to use donor sperm finds some man on the Internet who is saying ‘I am a sperm donor’ — it is completely uncontrolled and so they just deal with an individual and not with a sperm bank.

“Then you don’t have these safeguards of viral testing and there is a possibility of sexually transmitted disease… we have expressed concern that if donor sperm is restricted it will encourage unofficial, do-it-yourself sperm donors which, if you go on the Internet, apparently it is quite frightening; there are lots of men out there advertising their services as personal sperm donors. We think that is frightening… we have expressed that concern in communications to the Department of Health already.”

Contentious

He acknowledged that donor anonymity is a contentious area and even people working within assisted reproduction hold different views. Nevertheless, the position of the IFS is that a ban is not warranted.

“There will always be debates about anonymity for gamete donation, is it good or is it bad… but while it is uncertain, people should have the freedom to choose anonymity or identifiability, and that is the situation that has obtained for a couple of decades and I think it has worked out very well.”

Catherine Reilly

http://www.medicalindependent.ie/94291/the_ethics_of_fertility

Fertility treatment ‘works for most’

Nearly three out of four couples that begin fertility treatment will eventually become parents, long-term studies suggest.

The analysis of nearly 20,000 Danish couples found 65% had children within three years and 71% within five years.

Doctors, presenting their data at a fertility conference, said the odds were heavily influenced by age.

But experts said the findings were very encouraging for couples struggling to have babies.

There is strong evidence that about one in three cycles of IVF is successful in women under the age of 35.

But what happens in the long run, when some couples try over and over again, others give up and some have problems that cannot be treated, has been uncertain.

Researchers at the Copenhagen University Hospital used rigorous registry records in Denmark to follow 19,884 women from the moment they started fertility treatment.

The results, presented at the European Society of Human Reproduction and Embryology, showed that more than half had given birth within two years, rising to 71% after five years.

For women under 35, 80% had children within five years. But the figure fell to 61% in those between 35 and 40 years old; and fell again to 26% in women over 40.

Dr Sara Malchau, one of the researchers, told the BBC News website: “There is a very good chance of having a child, even if you have difficulties conceiving on your own.

“Most causes of infertility can be overcome, but age is the most important factor to predict if treatments are going to be successful or not.

“Also women with a body mass index under 30 had better outcomes as well as women who didn’t smoke.”

The study also found that nearly a fifth of the women under 35 ended up conceiving as a result of sex – despite having sought fertility treatment.

However, Dr Malchau cautioned Denmark prioritised fertility treatments that made it easier for women to keep trying. Many other countries are less generous.

Common causes of infertility

Women:

  • damage to the fallopian tubes
  • ovulatory problems
  • endometriosis
  • age
  • polycystic ovary syndrome
  • diabetes
  • being overweight or underweight
  • smoking

Men:

  • low sperm count
  • problems with the tubes carrying sperm
  • problems getting an erection or ejaculating
  • diabetes
  • being overweight

Prof Nick Macklon, from the University of Southampton, said: “It really does provide some encouraging news for those who are about to embark on the journey of fertility treatment – the chance of having a baby is good.

“There will always be individual factors that affect an individual’s prognosis, but overall it shows us fertility treatments are working.

“There’s been a lot of debate about whether women should be having their children earlier, most of the people in my field would be of the view that if you can start earlier then your chances of completing the family you desire is going to be much higher.”

Couple who Battled Infertility Expecting Child

An Irish Fertility Clinic has announced the first pregnancy as a result of an advanced new treatment, which aids couples battling with male infertility.

Waterstone Clinic announced that a couple is expecting their first child following a Microsurgical Testicular Sperm Extraction procedure, an innovative new technique which a male patient undergoes ahead of IVF.

The procedure, used successfully for the first time in Ireland, battles against male infertility and increases the possibility of conception without having to use donor sperm.

The fertility specialists report that the client in this case had previously had testicular surgery which affected his sperm reduction and fertility, however the procedure helped he and his partner achieve a successful pregnancy through IVF in its aftermath.

Waterstone Clinic’s Consultant Urologist and Andrologist, Dr Ivor Cullen said the procedure achieved a “landmark pregnancy”, the first of its kind in Ireland.

“This is a landmark pregnancy and very positive news regarding the treatment of male infertility and in particular azoospermia. Azoospermia is a condition where no sperm cells are found in a semen sample, perhaps as a result of a hormone imbalance or other medical problem. It offers renewed hope to these men, and to men who have been diagnosed with defective sperm production, or had previous unsuccessful conventional sperm retrieval procedures.”

The procedure is recommended to men who cannot produce sperm, and involves carrying out targeted dissection of tiny tubes within the testicle, which are more likely to contain sperm.

Head of Laboratory Services at Waterstone Clinic, Dr Tim Dineen, also commented “The team at Waterstone Clinic is delighted for this couple and would like to extend our congratulations. This procedure involved precise surgery and robust laboratory techniques; we will continue to pioneer innovative and evidence-based procedures and techniques, such as Micro-TESE, that help and benefit our patients overcoming their fertility struggles.”

http://www.independent.ie/life/family/family-features/irish-couple-who-battled-infertility-expecting-child-following-pioneering-treatment-in-cork-fertility-centre-34764510.html

Men with fertility issues can now be biological dads

A pioneering new treatment for men with fertility problems has led to its first reported pregnancy in Ireland.

The new technique increases the likelihood of men becoming fathers without needing to use donor semen.

Microsurgical Testicular Sperm Extraction (Micro-TESE) is used to extract viable sperm cells from men suffering from azoospermia, which means they have no or practically no sperm cells in their semen.

The now father-to-be had previously undergone testicular surgery which had affected his sperm production. However, he had Micro-TESE at Waterstone Clinic and then his partner underwent IVF successfully.

In Micro-Tese, an incision is made in the scrotum through which one or both testicles can be seen.

Tubes within the testicle tissue are then inspected with a special high-powered microscope and dissected to see if they contain a trace of sperm. The use of the microscope means that the sperm retrieval rates are much higher than they are using traditional Tese and less issue is removed from the testicle.

Men can have a low sperm count due to low testosterone levels, an injury, following surgery or because of medical problems.

Up to 30% of fertility problems in couples are believed to originate with the male, another 30% with the female, a further 30% are a combination of both the man and woman, while 10% are non-identifiable.

The successful Micro-Tese was performed by CFC’s consultant urologist and andrologist Dr Ivor Cullen at University Hospital Waterford.

Dr Cullen said: “This is a landmark pregnancy and positive news regarding the treatment of male infertility and in particular azoospermia. It offers renewed hope to these men, and to men who have been diagnosed with defective sperm production, or had previous unsuccessful conventional sperm retrieval procedures.”

Micro-Tese allows the urologist to better distinguish between healthy and unhealthy testicular tissue. The healthy tissue samples are later examined in the laboratory. If viable sperm is found, it is prepared and frozen for use in a subsequent IVF cycle.

CFC head of laboratory services, Dr Tim Dineen said azoospermia is either caused by a duct obstruction or else by other hormonal or medical factors.

Obstructions are normally dealt with by a traditional biopsy while cases, where no obstruction is evident, can be helped by Micro-Tese as it is “much more targeted than traditional Tese”.

CFC has offered in-house testicular biopsy — traditional Tese — for men with azoospermia for over a decade. Micro-Tese is the more advanced procedure.

Micro-Tese is a day procedure — the patient can walk out the same day. It costs approximately €5,000 while IVF costs over €4,200.

Dr Dineen added that Irish men are handling fertility problems better than they would have 10-15 years ago.

“Certainly there is more talk about male infertility and the taboo that was once there isn’t there as much, but compared to women’s ability to talk openly about it, they still aren’t quite there yet,” he added.

http://www.irishexaminer.com/ireland/men-with-fertility-issues-can-now-be-biological-dads-402749.html

First Pregnancy following Micro-TESE in Ireland

Waterstone Clinic has announced the first reported pregnancy as a result of an advanced sperm retrieval technique, Microsurgical Testicular Sperm Extraction (Micro-TESE) in Ireland. This development offers new hope to men struggling with sperm-related fertility issues. It means there is a greater possibility for affected couples to have children, without having to use donor semen.

The Micro-TESE procedure was carried out on a patient from Cork in conjunction with the centre’s scientific team, before the man and his partner underwent IVF treatment. The patient previously had testicular surgery which affected his sperm production, and as a result required Micro-TESE.

The procedure was performed by Waterstone Clinic’s Consultant Urologist and Andrologist, Dr Ivor Cullen at his practice in University Hospital Waterford. Dr Cullen is one of only a few urologists in Ireland qualified to carry out this highly specialised surgery.

Commenting on the success with Micro-TESE, Dr Cullen said “This is a landmark pregnancy and very positive news regarding the treatment of male infertility and in particular azoospermia. Azoospermia is a condition where no sperm cells are found in a semen sample, perhaps as a result of a hormone imbalance or other medical problem. It offers renewed hope to these men, and to men who have been diagnosed with defective sperm production, or had previous unsuccessful conventional sperm retrieval procedures.”

Micro-TESE is a welcome development in the treatment of men who cannot produce sperm. The procedure involves carrying out targeted dissection of tiny tubes within the testicle, which are more likely to contain sperm. A high powered microscope is used during the procedure to distinguish between healthy and unhealthy tissue. The healthy tissue samples are then examined in the laboratory. If viable sperm is found, it is prepared and frozen for use in a subsequent IVF cycle.

Head of Laboratory Services at Waterstone Clinic, Dr Tim Dineen, also commented “The team at Waterstone Clinic is delighted for this couple and would like to extend our congratulations. This procedure involved precise surgery and robust laboratory techniques; we will continue to pioneer innovative and evidence-based procedures and techniques, such as Micro-TESE, that help and benefit our patients overcoming their fertility struggles.”

Waterstone Clinic has carried out in-house testicular biopsy – known as TESE – for men with azoospermia for over a decade, and achieved their first birth through this technique in 2004. TESE is beneficial for azoospermic men whose basic problem is duct blockage. Micro-TESE is a more advanced procedure for men whose basic problem is failure to produce sperm cells. Both treatments are available at Waterstone Clinic.

Under the covers with mens sexual health issues

Under the covers with men’s sexual health issues

Do a quick Google search for womens health. You will receive approximately 152 million results. Do the same for mens health and you will get 22.3 million. Is this sexism in another guise, or is it purely indicative of male reluctance to discuss their health issues, even with Dr Google?

Consultant urologist and andrologist at University Hospital Waterford (UHW) Ivor Cullen says men should be aware that there is a wide range of solutions to many problems they may perceive as being embarrassing or distressing.

Cullen trained in several ground-breaking techniques during his time working in the leading urology centre at University College London Hospital. Many of these have not been available in Ireland until now.

Breakthroughs in fertility medicine have not just been confined to female fertility issues; the area of male infertility has seen a revolution in recent times, says Cullen.

Sexual dysfunction has also moved on from the “little blue pill”. When Viagra doesn’t work, there are many other options for men struggling with erectile dysfunction.

The important thing to remember is that no worrying or “embarrassing” health problem can be addressed if a man doesn’t approach his GP or health professional about it, Cullen says.

Erectile dysfunction

Erectile dysfunction affects about half of all men at some point in their lives. For some it may just be temporary, but for others it can be a persistent problem. For some this can be treated with physiotherapy and muscle re-education exercises. It can also be treated with medications – the phosphodiesterase type 5 inhibitors (such as Viagra). However, for those men who do not respond to these treatments, there is now the surgical option of an inflatable penile prosthesis.

As part of this procedure, hydraulic pumps are inserted so that men with erectile dysfunction can have functioning erections and have sex normally. Although this procedure has been offered in Ireland before, in Cullen’s opinion, the uptake has been quite poor, mainly owing to a lack of knowledge in the area among both patients and the health profession at large. “Penis implant surgery is just not requested or desired by patients as they are unaware of the option,” says Cullen, contrasting this with his experience in London where a significant proportion of men with ED are aware of and will choose the implant surgery as an option when the medications fail. “It has been offered to a limited number of patients in one or two centres. There is very little knowledge about penis implant surgery. No one talks about it here, but in other parts of the world that’s not the case, it’s quite commonplace.”

According to Cullen, common candidates for this procedure are younger men with type 1 diabetes who often ultimately get erectile dysfunction early in life, often starting after the age of 40 and medication eventually does not work. In addition, men who have had their prostates removed or had radiation or hormonal treatment, usually as a result of prostate cancer, would also benefit from this surgery, as the majority of these will lose the ability to have an erection and often will not respond to the usual medications.

The procedure can be carried out by Cullen and his team at UHW. A three-piece hydraulic inflatable implant is inserted, which isn’t visible externally. A small pump sits in the scrotum, much like a third testicle, explains Cullen. The two-piece prosthesis is implanted in the penis, while a reservoir is laced in the lower abdomen. When the pump is squeezed, the fluid goes from the reservoir into the prosthesis and makes it erect. This ensures a rigid erection every time, satisfactory for penetrative intercourse and dispensing with the need for expensive medications or injections. “Obviously that’s not for everyone but it is a fantastic addition to our options. Satisfaction rates with penile implant surgery are always remarkably high – 90-95 per cent. In a well-chosen patient who is properly counselled, it can be a wonderful option for erectile dysfunction,” Cullen says.

Curved penis

A curved penis, also known as Peyronie’s disease, affects 4-8 per cent of men, and can make normal intercourse impossible. “Peyronie’s disease does not refer to a mild curve,” explains Cullen. “Every man’s penis has a minor degree of curvature, but problems arise when there is over a 30-45 degrees of curvature, making penetrative sex impossible.

“The curve develops because of abnormal deposition of scar tissue – “plaque” in the erectile bodies within the penis – which shortens the affected side and results in curve development. “Men cannot have a satisfactory sex life due to the shape of their penis, which can resemble a boomerang.”

Several surgical options exist for patients, whereby the penis can be straightened. One possible option to correct the curvature is the Nesbit procedure, which involves plication (suturing) of a section of the penis opposite the problematic plaque or scar. This operation will usually ensure a straight penis albeit with a minor loss of length.

Other potential approaches range from injections of a digesting enzyme (collagenase) into the scar tissue to break it down, grafting procedures and potentially implant surgery, if the co-existing erectile dysfunction is significant. Again Cullen says that in most cases men are not forthcoming about what they might see as an embarrassing problem. “Men are often very bashful and shy and don’t talk about these problems with their partners or friends, much less see their doctors about them,” says Cullen.

“It can often be slowly destroying their relationship or marriage, and they need to understand that this is a recognised and correctable phenomenon, and easily fixable surgically.”

Male factor infertility

Male factor infertility contributes to approximately 50 per cent of cases of infertility and for men whose semen analysis is suboptimal, there are more treatment options than ever before. There is a plethora of reasons as to why someone might have what is deemed an “abnormal” semen analysis, says Cullen.

“They may have a low count, poor motility, or a low number of normal sperm forms. We evaluate them and investigate them and, in many cases, we have medical, surgical options or lifestyle interventions that can improve the quality of their sperm. It could be something as simple as stopping them from using daily saunas and Jacuzzis, to putting them on zinc and folic acid supplements.”

One of the more common reasons for a subnormal semen analysis is a varicose vein of the spermatic cord, known as a varicocoele. This condition can raise the temperature of the testicle and impair sperm production. “Lots of men have a minor degree varicocele, which is of no clinical significance, but when we find a significant varicocoele in a gentleman with an abnormal semen analysis, simply tying off the extra varicose veins will typically improve that man’s sperm analysis.” Unfortunately, there are also men with no sperm at all in their semen, a condition known as azoospermia. Cullen says these are the most challenging patients he will treat with respect to male infertility. “It is a devastating diagnosis for a man; they will usually have been trying for a family for 12-18 months before someone says, let’s get checked. To find out there is no sperm at all is just a disaster for them.”

Tests are carried out to determine if the condition is due to an obstruction in the transport of sperm cells from the testicle to the ejaculate, or if there is a fundamental problem with sperm production within the testis. The obstructive type could be due to scarring of the vas deferens or epididymis, sometimes as a result of chlamydia or gonorrhoea.

A hernia repair or undescended testicle repair may also be the culprit. This can often be treated with a procedure that is much like a vasectomy reversal. “With this scenario, it really isn’t the end of the world, because even if you can’t fix it, their testes are still full of sperm,” explains Cullen. If this is the case, an option is a intracytoplasmic sperm injection (ICSI), where the sperm is injected directly into the egg. This treatment is offered in a number of clinics in Ireland. “That works so well now that all we need is sperm.”

In cases of non-obstructive azoospermia, a man will have no sperm at all in his semen. Recent advances in treatment have meant that at last these men have therapeutic options.

In the past, these couples had no choice other than using donor sperm or going down the route of adoption. In particular, a technique known as microdissection testicular sperm extraction (micro-TESE), has revolutionised the approach to finding small numbers of hidden sperm for use in the ICSI procedure.

The technique is another Cullen learned during his time in London; he now offers the procedure in conjunction with the Waterstone Clinic. He warns, however, that there is only a 50/50 chance of “success”; small numbers of sperm will be located in approximately half of the men he treats, while no sperm will be found in the other 50 per cent. “What I am trying to do is find their sperm for use in ICSI or as part of an IVF regime. But before I carry out the procedure I like to make sure that couples have had a chance to discuss and develop a back-up plan and perhaps speak to the sperm donor service if they so wish. “When there is no success, it can be devastating for a couple, and anticipating and discussing the implications of not finding sperm in advance of the operation often helps tremendously.”

Andrology

Andrology (from Ancient Greek, Andros, meaning man) is the medical specialty that deals exclusively with male genital, reproductive and sexual health. It is the counterpart to gynaecology, which deals with medical issues specific to the female reproductive system. It is a recognised subspecialty of urological surgery. Although andrology is a well-established subspecialty in mainland Europe and also the UK, thus far Ireland has had low numbers of specialists trained in this field.

Cullen suspects this is because of the well-recognised need for prostate, bladder and kidney specialists in Ireland, with the majority of his contemporaries instead choosing these routes for subspecialisation. The area remains under-served in Ireland.

“Andrology is a fascinating subspecialty, which offers tremendous medical and surgical options to gentlemen with a variety of male specific ailments,” says Cullen, who has spent 13 years training in this area.

With men living longer and our increasingly elderly demographic, he says there is a need for particular focus to be paid to late onset hypogonadism – often termed the “male menopause” – in older men. Symptoms range from sexual, such as erectile dysfunction, physical, with a loss of vigour and frailty, as well as having significant psychological impact. This can be successfully treated with testosterone replacement therapy, although lifestyle modification, weight reduction and appropriate treatment of comorbid diseases is the first step, Cullen is keen to emphasise. “Symptoms of low testosterone are well recognised and correctable in the hands of a specialist, which can lead to tremendous improvement in cardiovascular, sexual, mental and metabolic health.”

http://www.irishtimes.com/life-and-style/health-family/under-the-covers-with-men-s-sexual-health-issues-1.2660563

Lack of Evidence for Adjuvant Treatments Confirmed

Waterstone Clinic takes pride in providing the highest standard of fertility treatment with evidence-based medicine the cornerstone of our good clinical practice.

We at Waterstone Clinic welcome the recent British Fertility Society practice guidelines published in Human Fertility, which confirms our long-standing belief that insufficient evidence exists to recommend adjuvants such as intravenous immunoglobulin (IVIG), anti –TNF α agents (e.g. Humira), intralipid infusions, corticosteroids, aspirin, sildenafil, DHEA or low molecular weight heparin in routine IVF practice.

Indeed, apart from the lack of evidence to support the use of these adjuvant therapies, the practice guideline emphasises the potential risks associated with these therapies, such as the risk of anaphylaxis and infection with IVIG and the increased risk of lymphoma, skin cancers and granulomatous infections with prolonged use of anti –TNF α agents. It is of paramount importance that patients prescribed unproven therapeutic agents have the available evidence for clinical benefit and the potential adverse effects discussed with them.

Waterstone Clinic continues to produce excellent success rates that are not reliant on the provision of therapies of unproven benefit.

Fertility Watchdog Increasingly Concerned About Dubious treatments

The UK’s fertility watchdog is becoming “increasingly concerned” that private clinics are offering ‘add-on’ treatments which have not been properly tested to see if they actually work, it can be revealed.

In a series of interviews with The Independent, leading experts variously claimed some clinics were giving out “expensive, potentially harmful stuff like Smarties”, announcing breakthroughs that were closer to marketing “hype” and that half of the people treated did not actually need any help to have a baby.

A Cambridge university immunologist also said the use of immune-suppressant drugs by clinics was based on a flawed theory that this could help prevent miscarriage and broke the medical maxim to “first do no harm”.

Despite regular announcements of new techniques, progress has been relatively modest. In the 10 years to 2013, the average birth rate following IVF rose from about 20 per cent per cycle of treatment to 26.5 per cent.

After the Human Fertilisation & Embryology Authority was contacted about the experts’ concerns, the HFEA’s chair Sally Cheshire said it was planning to take action to help patients decide which techniques were worthwhile.

“Although the vast majority of clinics provide excellent care for fertility patients, we are becoming increasingly concerned about IVF treatment ‘add-ons’ without a strong evidence base being offered at some clinics,” she said in a statement.

“We know from talking to patients that they can find navigating the IVF process difficult and the offer of ‘add-ons’ can increase their confusion, and the cost of their treatment.

“Patients are often not sure whether they need the additional treatments but worry that they could regret not making every attempt they can to get pregnant.”

She said the HFEA was now working with scientists and the industry to “provide accurate and easy-to-understand information about these new treatments”.

One of Britain’s leading fertility experts, Yacoub Khalaf, director of the assisted conception unit of at Guy’s and St Thomas’ Hospital in London, stressed that some of those working in private fertility clinics were “very decent and honest people”.

But he added: “At best, patients are subject to exploitation; at worst, patients are being subjected to harm.

“All of this needs to be subjected to rigorous checks — and a reality check among the providers and the users.”

Mr Khalaf said some fertility clinic staff were simply putting “two and two together” about treatments that appeared to show signs of success without waiting for genuine scientific proof.

He said there might be a small number of patients who would benefit from such treatments, but this was “not a recipe to just dish out expensive, potentially harmful stuff like Smarties”.

“Some patients, through their use of expensive, unproven medication, could be deprived of the financial resilience to try again,” he added.

IVF treatment was developed in the 1960s by Sir Robert Edwards in work that later won him the Nobel Prize and one of his first graduate students was Martin Johnson.

Now emeritus professor of reproductive sciences at Cambridge University and joint senior editor of the journal Reproductive BioMedicine and Society, he pointed to “a lack of scientific rigour” behind some fertility clinic techniques.

“What it means is the treatment could be making their situation worse and certainly not improving it — and is costing them money. It’s all about anecdotal evidence or no objective evidence,” Professor Johnson said.

He said he felt the people doing it generally acted in “good faith”. “People can believe something that isn’t necessarily true. I would not describe it as a scandal. It’s over-enthusiastic clinics hyping some of their treatments more than they should do so,” he said.

But when asked if he had an “understanding” attitude towards their actions, Professor Johnson disagreed, saying: “I’m trying to think of explanations for why people, who are otherwise ethical, might do this.”

Dr John Parsons, founder and former director of King’s College Hospital’s assisted conception unit and a trustee of the Progress Education Trust fertility and genetics charity, has more than 30 years’ experience in the field.

Now semi-retired, he said he felt “very strongly that the industry – whatever you want to call us – has used whatever is to hand, regardless of whether it works or not, ever since I’ve been involved”.

“Every time there was a new, in inverted commas, ‘breakthrough’, it was tried on everybody and anybody,” said Dr Parsons.

“It’s got a bad smell about it. It’s all about the money. I worked in King’s College Hospital and was paid an NHS salary, but you get tainted by it. That was a pretty unpleasant feeling.

“I genuinely believe at least 50 per cent of the people who got pregnant didn’t need our help.”

Perhaps the most alarming technique is the use of drugs to suppress specialised immune cells in the mother’s uterus.

Cambridge University immunologist Professor Ashley Moffett said the idea that the foetus might be attacked by its mother’s body because half the unborn baby’s DNA comes from the father was first suggested by Nobel Prize winning biologist Sir Peter Brian Medawar, known as the “father of transplantation”.

“That’s a very attractive idea, but it’s actually not correct. But it’s become firmly embedded and it’s extremely hard to dislodge it, even among scientists,” Professor Moffett said.

“There’s certainly no evidence that it [immune-suppression] does any good and there is the potential that it can do harm because these treatments are immunosuppressive.

“Risking immunosuppression in someone who is young and fit is to me … first do no harm.”

She said one woman given immunosuppressant drugs by a private clinic became pregnant, but also seriously ill with a fungal infection. After the infection got into her bloodstream, she “lost the baby as a result quite late in the pregnancy”.

“I think these women are quite obviously, one understands, desperate, desperate and they will try anything,” Professor Moffett said, adding that their financial exploitation was “very sad”.

Professor Adam Balen, chair of the British Fertility Society, which speaks on behalf of the industry, said the most important thing was for patients to be given a genuine choice.

“Clinics have to be transparent and be open and provide appropriate information about exactly what it is they are offering and provide their own statistics as to the potential prospects of success,” he said.

“All of these treatments have been tested around the world and have been studied in clinical trials – every single one. None have been shown to do harm.”

Professor Balen, a reproductive medicine consultant at Leeds Teaching Hospitals NHS Trust, said exploring new techniques was also useful in driving up the success rate, which he said could be as high as 50 per cent for the best clinics.

“It is acceptable to provide certain treatments that may not have been conclusively shown to be absolutely beneficial to everybody, provided patients are informed,” he added.

Asked about critics of this idea, he said: “There are some people who are very outspoken and may have an axe to grind.”

Source:http://www.independent.co.uk/life-style/health-and-families/health-news/fertility-watchdog-hfea-concerned-private-clinics-ivf-treatment-a7028751.html